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Abstract. Background: Improvement in overall survival (OS) is considered the ultimate reflection of clinical benefit for trials in acute myeloid leukemia (AML). Event-free survival (EFS) is a frequently reported outcome but is not universally considered as a robust end-point, as it is frequently a poor surrogate of OS.
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Left ventricular hypertrophy (LVH) detected by 12‐lead ECG 1, 2, 3 and by echocardiography 4, 5, 6, 7, 8 are common manifestations of preclinical cardiovascular disease that strongly predict cardiovascular morbidity and mortality.
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