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Ejection fraction (EF) measures the amount of blood pumped out of your heart 's lower chambers, or ventricles. It's the percentage of blood that leaves your ventricle when your heart contracts..
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Van Rooj et. al. demonstrated that the inhibition of miR-208a by systemic delivery of locked nucleic acid–modified antisense oligonucleotide prevented cardiac remodeling in a rat model of LV failure. This technology also prevented pathological myosin switching and cardiac remodeling, while improving cardiac function .
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